Sandalore

Sandalore is a synthetic fragrance compound designed to mimic the scent of natural sandalwood.

It is widely used in perfumes, cosmetics, and personal care products because of its rich, creamy, and woody aroma.

Sandalore is particularly interesting because it has been found to interact with olfactory receptors in the skin, potentially promoting hair growth and wound healing.

It is often used as a substitute for natural sandalwood oil, which is expensive and has sustainability concerns due to overharvesting of sandalwood trees.

Sandalore is a component of Sandalwood. Sandalore is not Sandalwood, but a part of Sandalwood. Together with Ebanol, and other Sandalwood odourants; it serves as an effective Sandalwood replacement. It has a fairly quiet odour by itself. It is a long life heavy base note molecule, almost undetectable from the bottle and best appreciated after appropriate dilution or when incorporated into a blend.

It has recently been recognised for its pheromone like responses.

Smell is a sensation triggered when molecules of “odorant” chemicals are recognised by special cells in the nose, but the processes underpinning this phenomenon are not confined to the nasal passages. In fact, the same chemical pathways help regulate a range of other cell functions in the body, including hair growth.

As the outermost barrier of the body, the skin is exposed to multiple environmental factors, including temperature, humidity, mechanical stress, and chemical stimuli such as odorants that are often used in cosmetic articles. Keratinocytes, the major cell type of the epidermal layer, express a variety of different sensory receptors that enable them to react to various environmental stimuli and process information in the skin.

Subsequent research has found that by applying Sandalore to scalp tissue they could both increase hair growth and decrease cell death. Intriguingly, the results suggest that human hair follicles can “smell”, in the sense that they make use of ancient smell receptors to control key functions such as growth. Researchers focused on a receptor called OR2AT4, which is known to be stimulated by Sandalore, and which can be found in the outer layer of hair follicles.

Sandalore was also found to induce strong Ca2+ signals in cultured human keratinocytes. Moreover, the long-term stimulation of keratinocytes with Sandalore positively affected cell proliferation and migration, and regeneration of keratinocyte monolayers in an in vitro wound scratch assay. These findings combined with studies on human skin organ cultures strongly indicate that the OR 2AT4 is involved in human keratinocyte re-epithelialization during wound-healing processes.

If you plan to self-medicate with Sandalore, please proceed with caution. We do not sell this or any material as a medicine or for any use other than as an ingredient in a perfume blended and diluted by a competent person.