About this material
ISO E Super TOCO is a modern masterpiece of fragrance chemistry; a luxurious, woody-amber molecule prized for its smooth, velvety, sophisticated scent and remarkable versatility.
This enhanced version of the iconic Iso E Super; manufactured by IFF results in a beautifully consistent ingredient that performs impeccably across fine fragrances, colognes and scented body products.
Its scent is velvety, musky, and amber-woody, with an almost magnetic softness that lingers on the skin.
While subtle on its own, ISO E Super TOCO reveals its full character in blends; adding depth, warmth, and diffusion to compositions and enhancing other notes without overpowering them.
A true cornerstone of modern perfumery, Iso E Super has been used in iconic creations such as Dior Sauvage and was revolutionized by Escentric Molecules’ Molecule 01.
For the untrained nose, ISO E Super TOCO may be barely perceptible; yet it leaves an unmistakable trail of sophistication that lingers long after the first impression.
While some believe ISO E Super has pheromonal qualities, this remains anecdotal; unlike Hedione, whose sensual effects are supported by research.
For perfumers seeking even greater impact, related materials include Timbersilk and Sylvamber, both offering intensified woody-amber characters that are based on the same DNA.
Tocopherol helps maintain the integrity of the fragrance molecule during storage, processing and in challenging formulation matrices (e.g. heat, light, air exposure).
Proividing excellent stability and with improved longevity, perfumers using ISO E Super TOCO can expect the same olfactive beauty as the original; but with greater confidence in its resistance to oxidation, discoloration, and degradation over time. This enhanced reliability makes it a highly sought-after choice among perfumers dedicated to crafting exceptional, long-lasting creations of uncompromising quality.
Scent character
Highlights from the material’s listed odour profile.
Note position
Base note
Material character
A closer lookOdour strength
Listed qualitative strength
Tenacity / substantivity
48 hour(s)
at 100%
Listed reference conditions
Fragrance development
Base note
Illustrative note development · no measured evaporation data
Molecular identity
C16H26O
- Molecular weight
- 234.38 g/mol
- IUPAC name
- 1-(2,3,8,8-tetramethyl-1,3,5,6,7,8a-hexahydronaphthalen-2-yl)ethanone
More compound properties
Computed and structural reference properties for the named compound. These are not measured supplier specifications or properties of a complete dilution, mixture or batch.
- XLogP (computed)
- 3.8
- Exact mass (Da)
- 234.198365449
- Monoisotopic mass (Da)
- 234.198365449
- Topological polar surface area (Ų)
- 17.1
- Complexity
- 364
- Formal charge
- 0
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 1
- Heavy atoms
- 17
- Isotope atoms
- 0
- Atom stereocentres
- 3
- Bond stereocentres
- 0
- Covalent units
- 1
- SMILES
- CC1C=C2CCCC(C2CC1(C)C(=O)C)(C)C
- InChI
- InChI=1S/C16H26O/c1-11-9-13-7-6-8-15(3,4)14(13)10-16(11,5)12(2)17/h9,11,14H,6-8,10H2,1-5H3
- InChIKey
- NOMWSTMYQKABST-UHFFFAOYSA-N
Reference data checked 2026-10-27.
This molecular reference matches the catalogue’s recorded CAS and formula. It does not confirm the supplied grade, purity, stereochemistry, isomer proportions, composition, impurities or unlisted constituents.
Fragrance allergen reference
Generic regulatory reference only. This is not a supplier allergen declaration, measured composition, allergen-free claim or finished-product labelling assessment.
Raw-material reference based on recorded CAS numbers. A CAS match identifies a reference entry; it does not verify the supplied grade, composition, purity or finished-product compliance. Naturals, bases and mixtures require composition review.
European Union / Northern Ireland
- Tetramethyl Acetyloctahydronaphthalenes — Annex III entry 344; substance-group reference. Recorded CAS match only; composition and scope require assessment.
Finished-cosmetic declaration thresholds: greater than 0.001% leave-on; greater than 0.01% rinse-off. Apply the current target-market rules to the actual complete formulation; no concentration is inferred here.
Commission Regulation (EU) 2023/1545 · Regulation (EU) 2023/1545 with 11 November 2025 corrigendum; checked 2026-10-26.
Held EU transition dates: placing noncompliant products on the market until 2026-07-31; making them available until 2028-07-31. Check applicability and current law for the intended market. 2025 corrigendum.
Great Britain
No direct listed-entry CAS match in this jurisdiction’s held reference set. This does not mean the material is allergen-free. Constituents, grouped entries and natural-material composition may require further review.
Finished-cosmetic declaration thresholds: greater than 0.001% leave-on; greater than 0.01% rinse-off. Apply the current target-market rules to the actual complete formulation; no concentration is inferred here.
Regulation (EC) No 1223/2009, Annex III (Great Britain) · legislation.gov.uk current text checked 2026-10-26.
Current supplier composition or allergen declarations are required to assess naturals, bases, mixtures and actual concentrations. Reference data checked 2026-10-26; bundle 2026-10-27. Supplementary private documents remain separate.
Product specification
| CAS number | 68155-66-8 |
|---|---|
| Odour description (decreasing) | Velvety, Silky, Woody, Dry, Amber, Musky, Smooth, Warm. Diffusive & Fixative |
| Odour strength | Medium - soft but diffusive; long-lasting base note |
| Perfumery use | Effective from the smallest traces up to 21.4%Listed perfumery guidance; this is not an IFRA limit. |
| Substantivity | 48 hour(s) at 100% |
| Solvent | None |
| Physical state | Liquid |
| Synonyms | OTNE, Octahydrotetramethyl Acetophenone, Patchouli Ethanone, Tetramethyl Acetyloctahydronaphthalenes, Iso Gamma Super, Anthamber, Amber Fleur, Boisvelone, Iso Ambois, Amberlan, Iso Velvetone, Orbitone, Amberonne. |
| Recorded name / preparation | 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one |
| Molecular formula | C₁₆H₂₆O |
Additional listed details
Threshold: Low odour threshold (detectable at trace levels in blends)
Safety & handling
Contains: Tetramethyl Acetyloctahydronaphthalenes (68155-66-8, 54464-57-2, 68155-67-9, 54464-59-4), Tocopherol (10191-41-0)
Hazard statements:
- H315 Causes skin irritation.
- H317 May cause an allergic skin reaction.
- H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements:
- P261 Avoid breathing mist or vapours.
- P264 Wash skin thoroughly after handling.
- P280 Wear protective gloves.
- P333+P313 If skin irritation or rash occurs: Get medical advice/ attention.
- P391 Collect spillage.
- P501 Dispose of contents/ container to an approved waste disposal plant.
Professional/Industrial use only.
Datasheets & customer documents
Available documents are attached to eligible completed orders in your account.
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Supplementary documents are supplied only where explicitly listed and available. Check documentation information
Purchased as a guest? Follow the SDS request guidance in our Documentation Supply Policy and provide proof of purchase.
Documentation Supply PolicyIFRA formulation guide
Generic reference only — not an IFRA certificate, compliance decision or use recommendation. The Responsible Person and qualified safety assessor must assess the actual finished formula using current applicable IFRA Standards, supplementary documentation where available and the CPSR.
Raw-material reference based on recorded CAS numbers. A CAS match identifies a reference entry; it does not verify the supplied grade, composition, purity or finished-product compliance. Naturals, bases and mixtures require composition review.
Source: 51st Amendment overview, held source checked 2026-10-21. Bundle 2026-10-27. Individual Standards prevail over the overview.
1-(1,2,3,4,5,6,7,8 Octahydro-2,3,8,8-tetramethyl-2-naphthalenyl) ethanone (OTNE)
RESTRICTION · CAS 54464-57-2, 54464-59-4, 68155-66-8, 68155-67-9
Category 4 — fine fragrance: 20% in the finished consumer product
All applicable specification, purity and other Standard conditions must also be met.
All IFRA categories and Standard conditions
| Category 1 | 0.41% in the finished consumer product |
|---|---|
| Category 2 | 1.1% in the finished consumer product |
| Category 3 | 0.41% in the finished consumer product |
| Category 4 | 20% in the finished consumer product |
| Category 5A | 5.1% in the finished consumer product |
| Category 5B | 0.56% in the finished consumer product |
| Category 5C | 0.76% in the finished consumer product |
| Category 5D | 0.19% in the finished consumer product |
| Category 6 | 0.0093% in the finished consumer product |
| Category 7A | 0.67% in the finished consumer product |
| Category 7B | 0.67% in the finished consumer product |
| Category 8 | 0.19% in the finished consumer product |
| Category 9 | 2.4% in the finished consumer product |
| Category 10A | 2.4% in the finished consumer product |
| Category 10B | 6.6% in the finished consumer product |
| Category 11A | 0.19% in the finished consumer product |
| Category 11B | 0.19% in the finished consumer product |
| Category 12 | No numeric restriction in this overview cell; review the full Standard and other applicable requirements. |
CAS numbers (comment): The scope of this Standard includes, but is not limited to the CAS number(s) indicated above; any other CAS number(s) used to identify this fragrance ingredient should be considered in scope as well.
Contributions from other sources: None to consider
Flavor use consideration: Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.
IFRA Standard type: RESTRICTION
Intrinsic property driving the risk management measure: DERMAL SENSITIZATION AND SYSTEMIC TOXICITY
Amendment revised: 49
Existing creations deadline: February 10, 2022
New creations deadline: February 10, 2021
IFRA source overview · Individual IFRA Standards and supplementary documentation
Supplier certificates and private documents are separate evidence. Their availability does not determine whether this generic guide is shown. This is a dated local reference, not a live regulatory feed.
Creative ideas to explore
Creative directions, not tested formulas.Woods in daylight
With bergamot and a crisp citrus openingExplore a spare wood structure with citrus providing the opening contrast. Compare a brighter version with the wood reference and follow how the outline changes, keeping the later impression as important as the first moment.
A softer grain
With sandalwood and a musk directionSet the woody material beside a softer wood reference, then compare a restrained musk variation. Decide whether your concept needs creamy texture, dry definition or more space between its parts before expanding the accord.
Petals on timber
With rose and a clear floral accordTry a flower-and-wood study in which both subjects remain recognisable. Compare the floral reference with the woody variation through the evaluation, noting whether the wood forms a useful backdrop or becomes the centre of the idea.








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